Fast Healthcare Interoperability Resources (FHIR) specifications are used to exchange clinical and health related information between different systems. There is unfinished on-going work to represent FHIR resources using Semantic Web technology to support semantic interoperability. This same technology would then also fit applications doing reasoning. We utilize and customize the FHIR unofficial draft ontology for doing drug-drug interactions reasoning. We give one use case of such reasoning based on family history; this kind of reasoning may extend the capabilities given by Forskrivnings- og ekspedisjonsstøtte (FEST) alone. We achieve this by setting up a FHIR server and making a FHIR client that store drug and patient information to the server; we then later retrieve some of this information, translated it into Web Ontology Language (OWL) based ontology, do drug-drug interaction (DDI) reasoning exposing potential health risks.
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